Sense of emptiness
Whether it is something you have desired or not, after the initial excitement and sense of freedom has worn off, you can be left feeling empty, with no sense of purpose.
You can even lose your sense of who you are. So often, when we think about or talk about ourselves in social situations, we define who we are by what we do. This is particularly the case if you have loved your work and it has given great meaning to your life.